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Personalizing subject lines does not mean putting someone's first name in the subject line, followed by generic information such as, "Loren, Your Personalized May Newsletter." If you are segmenting your list in any way, then each segment should likely receive appropriate and different subject lines. Even if you aren't creating separate versions of your email, if you have relevant information on segments of your subscribers, tailoring the subject line to their interests should improve open and click-through rates.
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